Table 1.
Differences in Clinical and Biochemical Characteristics among NGT, IGT and DM patients.
| TOTAL | NGT | IGR | DM | P | |
|---|---|---|---|---|---|
| N | 1852 | 623 | 752 | 477 | |
| Age (years) | 62.76 ± 0.23 | 61.06 ± 0.41 | 63.65 ± 0.37 | 63.57 ± 0.44 | < 0.001 |
| Male:Female | 1397:455 | 490:133 | 557:195 | 350:127 | |
| Post menopause (n) | 331 | 93 | 138 | 100 | |
| Smoke rate | 0.4968 | 0.4992 | 0.4973 | 0.4926 | NS |
| CHD rate | 0.8229 | 0.7833 | 0.8271 | 86.79 | 0.002 |
| BMI (kg/m2) | 24.79 ± 0.07 | 24.43 ± 0.12 | 24.82 ± 0.11 | 25.22 ± 0.14 | < 0.001 |
| WHR | 0.96 ± 0.01 | 0.94 ± 0.01 | 0.97 ± 0.02 | 0.96 ± 0.01 | NS |
| SBP (mmHg) | 128.91 ± 0.33 | 127.85 ± 0.56 | 128.12 ± 0.49 | 131.55 ± 0.68 | < 0.001 |
| DBP (mmHg) | 77.54 ± 0.21 | 77.59 ± 0.35 | 77.58 ± 0.36 | 77.41 ± 0.37 | NS |
| FBG (mmol/l) | 5.71 ± 0.04 | 4.98 ± 0.02 | 5.33 ± 0.03 | 7.29 ± 0.11 | < 0.001 |
| PBG (mmol/l) | 9.26 ± 0.09 | 7.04 ± 0.08 | 8.42 ± 0.10 | 13.39 ± 0.20 | < 0.001 |
| FINS (uIU/ml) | 13.46 ± 0.75 | 9.74 ± 0.48 | 11.36 ± 0.45 | 21.78 ± 2.71 | < 0.001 |
| PINS (uIU/ml) | 81.62 ± 1.85 | 74.58 ± 2.90 | 93.03 ± 3.11 | 72.77 ± 3.51 | < 0.001 |
| GA (%) | 15.09 ± 0.08 | 13.23 ± 0.05 | 14.08 ± 0.07 | 19.11 ± 0.20 | < 0.001 |
| HbA1c (%) | 6.19 ± 0.03 | 5.34 ± 0.01 | 5.97 ± 0.01 | 7.66 ± 0.56 | < 0.001 |
| TC (mmol/l) | 3.92 ± 0.02 | 3.92 ± 0.04 | 3.95 ± 0.03 | 3.89 ± 0.05 | NS |
| TG (mmol/l) | 1.78 ± 0.03 | 1.63 ± 0.04 | 1.78 ± 0.04 | 1.99 ± 0.10 | < 0.001 |
| LDL (mmol/l) | 2.01 ± 0.02 | 2.02 ± 0.04 | 2.02 ± 0.03 | 1.96 ± 0.04 | NS |
| HDL (mmol/l) | 1.16 ± 0.01 | 1.19 ± 0.01 | 1.16 ± 0.01 | 1.10 ± 0.01 | < 0.001 |
| ApoA1 (mmol/l) | 1.21 ± 0.01 | 1.23 ± 0.01 | 1.22 ± 0.01 | 1.19 ± 0.01 | 0.009 |
| ApoB (mmol/l) | 0.70 ± 0.01 | 0.69 ± 0.01 | 0.71 ± 0.01 | 0.71 ± 0.01 | NS |
| ApoE (mmol/l) | 35.38 ± 0.40 | 34.48 ± 0.60 | 36.01 ± 0.60 | 35.58 ± 0.93 | NS |
| Lp (a) | 393.91 ± 11.19 | 414.08 ± 19.86 | 399.30 ± 17.63 | 359.05 ± 20.97 | NS |
| Scr (umol/l) | 80.28 ± 0.52 | 80.28 ± 0.78 | 81.46 ± 0.82 | 78.45 ± 1.16 | NS |
| UA (umol/l) | 333.49 ± 2.11 | 335.59 ± 3.54 | 341.24 ± 3.28 | 318.60 ± 4.30 | < 0.001 |
| Gensini score | 36.72 ± 0.98 | 30.18 ± 1.39 | 36.15 ± 1.58 | 46.15 ± 2.13 | < 0.001 |
| HOMAIR | 3.83 ± 0.30 | 2.22 ± 0.13 | 2.73 ± 0.12 | 7.75 ± 1.12 | < 0.001 |
| HOMAB | 213.41 ± 45.90 | 170.79 ± 20.51 | 304.64 ± 113.89 | 130.67 ± 21.67 | NS |
Abbreviations: CHD, Coronary Heart Disease; SBP, Systolic Blood Pressure; DBP, Diastolic Blood Pressure; BG, blood glucose; FBG, fasting blood glucose; PBG, 2h postprandial blood glucose; FINS, fasting insulin; PINS, 2h postprandial insulin; GA, glycated albumin; HbA1c, Hemoglobin A1C; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides; Scr, serum creatinine; UA, Uric Acid; BMI, body mass index; WHR, waist hip rate Baseline characteristics of study population was shown in Table 1. Continuous variables were presented as mean ± SD and categorical variables were shown in absolute numbers or percentages. Patients were classified into NGT, IGR and diabetes based on glycemic state according to the 1999 World Health Organization criteria. Chi-square test was used for analysis of categorical variables and ANOVA for continuous variables. NS, not significant.