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. 2017 Oct 27;7:14189. doi: 10.1038/s41598-017-13839-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Longitudinal mean power spectra in 1–100 Hz from HPC-CA1 injection ipsilateral and their contralateral sites over the second week through to the last recordings (weeks 20) post-administration of buffer (black) and K18 (green). (b) Early drop of the power spectra in the slow theta frequency band starting on week 4, which became strong on week 20. Data are presented as mean values ± SEM and black bar above curves indicates interval of significant level difference between buffer (black, n = 9) and K18 (green, n = 8) groups. 3 animals across different conditions were discarded from the analysis because of signal artifacts.