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. 2017 Oct 27;7:14276. doi: 10.1038/s41598-017-14622-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SFRP4 gene expression in prostate cancer. (a) Log₂ fold change of SFRP4 expression in cancer compared with normal samples (b) Log₂ fold change of SFRP4 expression in high Grade Group (3–5) compared with low Grade Group (1–2) samples. (c) Forest plot and meta-analysis of SFRP4 expression in prostate cancer compared with normal prostate samples. (d) Forest plot and meta-analysis of SFRP4 expression in high Grade Group compared with low Grade Group prostate cancer samples. Abbreviations: ns - not significant, GG – Grade Group, CI – confidence interval. ^aIn the Erho et al. cohort, low Grade Group included GG 1–3, and high Grade Group included GG 4–5.