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. 2017 Oct 27;7:14276. doi: 10.1038/s41598-017-14622-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Univariate Cox proportional hazard analysis of SFRP4 expression and follow-up endpoints. SFRP4 gene expression was used as a continuous variable in the analyses. Meta-analysis was performed on the cohorts with microarray based SFRP4 gene expression data and biochemical recurrence (PSA ≥ 0.2 ng/mL) as endpoint. For the cohorts with multiple samples per patients (study and Wang et al. cohort), one sample per patient was selected by random. Abbreviations: CI – confidence interval, HR – hazard ratio, BCR – biochemical recurrence. ^aThe Erho et al. cohort was analysed by logistic regression, with odds ratio as the effect size.