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. 2017 Oct 27;7:14200. doi: 10.1038/s41598-017-14314-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential methylation between ccRCC and adjacent tissue. (A) Volcano plot showing the distribution of CpG sites from the site-level test assessed by methylation differences and adjusted P values. All of CpGs are with FDR < 1E-10, CpGs in blue are differentially methylated more than 0.2 or less than −0.2; (B) Heatmap of differentially methylated CpGs within promoters between ccRCCs and adjacent tissues. Hierarchical clustering by 265 ccRCCs (pink color bar) and 133 adjacent tissues (blue-green color bar) with 986 significant CpGs within promoters (FDR < 1E-10, |Delta Beta| > 0.2); Red/blue gradient represents beta values of the methylation sites; (C) Promoter region distribution of promoter differential methylated CpG sites; (D) CpG island distribution of promoter differential methylated CpG sites; (E) Venn diagram showing the overlaps of the genes with the differential promoter methylation and mRNA regulation.