Table 1.
Specific GO and KEGG pathways of the cluster specific genes indicated in Fig. 3.
| Term | Gene Nr. | PValue |
|---|---|---|
| Cluster 1 | ||
| GO:0009888~tissue development | 49 | 7.76E-12 |
| GO:0001568~blood vessel development | 24 | 5.57E-08 |
| GO:0001944~vasculature development | 24 | 8.69E-08 |
| GO:0048706~embryonic skeletal system development | 14 | 1.43E-07 |
| GO:0060348~bone development | 15 | 1.58E-06 |
| GO:0051216~cartilage development | 12 | 3.86E-06 |
| GO:0007420~brain development | 23 | 3.90E-06 |
| GO:0001649~osteoblast differentiation | 9 | 2.02E-05 |
| GO:0007417~central nervous system development | 25 | 2.20E-05 |
| GO:0030900~forebrain development | 15 | 8.57E-05 |
| mmu05414:Dilated cardiomyopathy | 11 | 2.16E-04 |
| GO:0060485~mesenchyme development | 8 | 2.41E-04 |
| GO:0043009~chordate embryonic development | 24 | 4.31E-04 |
| GO:0030324~lung development | 10 | 0.0019 |
| GO:0050767~regulation of neurogenesis | 10 | 0.0062 |
| GO:0001654~eye development | 11 | 0.0065 |
| GO:0030902~hindbrain development | 7 | 0.0067 |
| Cluster 4 | ||
| GO:0009888~tissue development | 46 | 1.87E-13 |
| GO:0001568~blood vessel development | 27 | 4.74E-12 |
| GO:0001944~vasculature development | 27 | 8.28E-12 |
| GO:0007507~heart development | 22 | 5.64E-09 |
| GO:0060429~epithelium development | 23 | 3.70E-08 |
| GO:0030324~lung development | 13 | 2.71E-06 |
| GO:0060485~mesenchyme development | 9 | 7.00E-06 |
| GO:0048732~gland development | 16 | 1.27E-05 |
| GO:0007517~muscle organ development | 15 | 1.51E-05 |
| GO:0009952~anterior/posterior pattern formation | 14 | 1.52E-05 |
| GO:0014032~neural crest cell development | 7 | 4.80E-05 |
| mmu04510:Focal adhesion | 14 | 6.91E-05 |
| GO:0022008~neurogenesis | 26 | 1.07E-04 |
| GO:0060348~bone development | 11 | 1.51E-04 |
| GO:0001656~metanephros development | 8 | 1.70E-04 |
| GO:0030326~embryonic limb morphogenesis | 9 | 8.25E-04 |
| GO:0007420~brain development | 16 | 8.65E04 |
| Cluster 2 | ||
| mmu00982:Drug metabolism | 23 | 3.08E-18 |
| mmu00980:Metabolism of xenobiotics by cytochrome P450 | 19 | 1.90E-14 |
| mmu00830:Retinol metabolism | 19 | 3.39E-14 |
| GO:0009888~tissue development | 34 | 1.14E-07 |
| GO:0060429~epithelium development | 21 | 1.92E-07 |
| mmu00140:Steroid hormone biosynthesis | 10 | 1.50E-06 |
| mmu00983:Drug metabolism | 10 | 2.66E-06 |
| GO:0008202~steroid metabolic process | 14 | 1.08E-05 |
| mmu00590:Arachidonic acid metabolism | 10 | 2.43E-04 |
| GO:0008544~epidermis development | 10 | 5.85E-04 |
| GO:0007398~ectoderm development | 10 | 9.15E-04 |
| Cluster 3 | ||
| GO:0007126~meiosis | 11 | 5.73E-07 |
| GO:0005634~nucleus | 89 | 7.74E-06 |
| GO:0000279~M phase | 15 | 6.85E-05 |
| GO:0004089~carbonate dehydratase activity | 5 | 1.02E-04 |
| mmu00270:Cysteine and methionine metabolism | 5 | 7.46E-04 |
| GO:0000775~chromosome, centromeric region | 8 | 8.26E-04 |
| GO:0007283~spermatogenesis | 10 | 0.0125 |
| GO:0006006~glucose metabolic process | 7 | 0.0166 |
| mmu00480:Glutathione metabolism | 4 | 0.0279 |
| Cluster 5 | ||
| GO:0005634~nucleus | 208 | 2.83E-40 |
| GO:0006259~DNA metabolic process | 57 | 1.26E-27 |
| GO:0000279~M phase | 46 | 1.66E-25 |
| GO:0005730~nucleolus | 37 | 1.60E-16 |
| mmu04110:Cell cycle | 17 | 2.62E-09 |
| mmu03030:DNA replication | 8 | 4.07E-06 |
| GO:0006310~DNA recombination | 11 | 7.53E-06 |
| GO:0007126~meiosis | 11 | 3.16E-05 |
| GO:0051327~M phase of meiotic cell cycle | 11 | 3.16E-05 |
| mmu04115:p53 signaling pathway | 9 | 5.43E-05 |
| GO:0005654~nucleoplasm | 28 | 3.18E-04 |
| GO:0034470~ncRNA processing | 12 | 0.001 |
| GO:0040029~regulation of gene expression, epigenetic | 7 | 0.005 |
| GO:0006913~nucleocytoplasmic transport | 8 | 0.006 |
| GO:0046930~pore complex | 6 | 0.022 |
| GO:0007498~mesoderm development | 5 | 0.045 |
| mmu00051:Fructose and mannose metabolism | 5 | 0.005 |
| Cluster 6 | ||
| mmu04610:Complement and coagulation cascades | 31 | 8.09E-21 |
| GO:0002526~acute inflammatory response | 26 | 2.41E-17 |
| GO:0007596~blood coagulation | 22 | 1.83E-14 |
| GO:0019724~B cell mediated immunity | 16 | 5.99E-09 |
| GO:0043292~contractile fiber | 18 | 1.85E-08 |
| GO:0060429~epithelium development | 28 | 1.35E-06 |
| GO:0001944~vasculature development | 24 | 2.98E-05 |
| GO:0019752~carboxylic acid metabolic process | 35 | 1.00E-04 |
| GO:0048732~gland development | 17 | 0.0018 |
| GO:0050873~brown fat cell differentiation | 6 | 0.0032 |
| GO:0007398~ectoderm development | 12 | 0.0079 |
| GO:0031016~pancreas development | 5 | 0.041 |
| Cluster 7 | ||
| GO:0019827~stem cell maintenance | 9 | 2.69E-09 |
| GO:0048864~stem cell development | 9 | 4.07E-09 |
| GO:0005634~nucleus | 115 | 1.94E-07 |
| GO:0010468~regulation of gene expression | 73 | 5.93E-06 |
| GO:0007283~spermatogenesis | 16 | 6.50E-05 |
| GO:0007498~mesoderm development | 6 | 0.004 |
| GO:0007398~ectoderm development | 6 | 0.095 |
| GO:0007492~endoderm development | 3 | 0.096 |