Table 3.

Analysis of ALS responses to MPN and LPS in participants challenged with Salmonella Paratyphi A and diagnosed with paratyphoid infection.

	Geometric mean (95% CI)	Fold change from baseline* (95% CI)	p*	p (Type III)#
MP
Baseline	7.3 (7.0, 7.6)
PD	19.2 (13.5, 27.2)	2.54 (1.76, 3.66)	<0.0001	0.072
PD+48 h	17.3 (10.9, 27.4)	2.29 (1.59, 3.3)	<0.0001
PD+96 h	30.5 (20.1, 46.1)	4.03 (2.8, 5.81)	<0.0001
LPS
Baseline	7.2 (6.9, 7.5)
PD	15.2 (10.3, 22.5)	2.07 (1.4, 3.06)	<0.0001	0.085
PD+48 h	16.7 (10.8, 25.8)	2.28 (1.54, 3.36)	<0.0001
PD+96 h	27.1 (17.0, 41.0)	3.7 (2.51, 5.46)	<0.0001

Output are from mixed effects models with a random intercept for each participant. Variables for dose and visit included in the model as fixed effects.

^*Adjusted for challenge dose received (high or low).

^#P-value testing whether change from baseline is different across visits. PD, Day of paratyphoid diagnosis.