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Macrocycle 6ad binding to MDM2 receptor (details SI). A: Modelling of 6ad into MDM2 receptor (PDB ID 1YCR); B: 2D structure of 6ad; C: Superimposed 1H-15N HSQC NMR spectra 15N-labelled MDM2 titrated with 6ad: blue - reference MDM2 spectrum, red – 4:1 (MDM2:6ad) titration step, green – 1:5 (MDM2:6ad; overtitration).
