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. 2017 Oct 23;8:2059. doi: 10.3389/fmicb.2017.02059

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Copyright © 2017 Pietrobon, Bononi, Lotito, Perri, Violanti, Mazzoni, Martini and Tognon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serologic profile of serum antibody reactivity to BKPyV mimotopes VP1 L (A) and VP1 M (B) and VP1 L+M (C). Immunologic data are from CN and HS serum samples. Results are presented as values of optical density (OD) readings at λ 405 nm of serum samples diluted at 1:20, detected by the indirect enzyme-linked immunosorbent assay. In scatter dot plotting, each plot represents the dispersion of OD values to a mean level indicated by the line inside the scatter with SEM for each group of patients/subjects analyzed. (A) The mean OD for VP1 L in CN and HS does not differ statistically, while (B) the mean OD of sera (VP1 M ± Std Error) in CN (0.326 ± 0.008) is higher than that detected in HS (0.417 ± 0.021). (C) The mean OD of sera (VP1 B+C ± Std Error) in CN (0.329 ± 0.015) is lower than that detected in HS (0.372 ± 0.012). Statistical analyses were performed using t-test.