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Expression of brc1-G136A, -TH148,149SG, and -R268K rescues brc1Δ and smc6-74 MMS sensitivity. Constructs were expressed from the moderate strength nmt41 promoter in plasmid pREP41X and tested for rescue of brc1Δ (A) or suppression of smc6-74 (B). In each panel, rows 1 and 3 contain cells transformed with empty pREP41X.
