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E6AP regulation at T485 has no effect on HPV E6 degradation of p53. E6AP-null HEK293 cells were transfected with plasmids expressing E6AP and p53 as indicated, plus plasmids expressing either HPV-16 E6 (A), HPV-18 E6 (B), or HPV-31 E6 (C). After 24 h the cells were harvested and protein levels analyzed by Western blotting. β-Galactosidase acted as a control for transfection efficiency in all assays.
