Figure 1.

BrCa-Core Complex Discovery

(A) An integrated protein-protein interaction network is combined with tumor proteomic profiles to identify sets of densely connected proteins that display correlated expression profiles across tumor proteomes. By comparing the results with those derived from randomly relabeled protein interaction networks, we can estimate the false discovery rate (FDR). The BrCa-Core set contains 285 complexes at an estimated FDR of 10%.

(B) BrCa-Core 17: the COP9 signalosome. The heatmap on the right shows protein expression of all subunits across 77 breast tumor proteomes. These have been sorted based on the mean abundance of all subunits.

(C) BrCa-Core 14: the conserved oligomeric Golgi (COG) complex.

(D) BrCa-Core 47 contains the ORC2–5 complex found in CORUM with the addition of LRWD1.

(E) BrCa-Core 25, the COPI complex.

(F) BrCa-Core 48, the EARP complex with the recently identified EARP interactor TSSC1.

(G) BrCa-Core 26, the Commander complex.