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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Nat Genet. 2017 Sep 11;49(10):1437–1449. doi: 10.1038/ng.3947

Figure 2.

Figure 2

Ranking KDGs of the CIC IBD networks. One hundred and thirty-three KDGs were identified and scored with respect to genetic association to IBD, involvement in inflammatory processes associated with IBD, and association with IBD-related clinical traits. The KDGs are listed clockwise around the disk in rank order, starting with the top ranked KDG at the top of the disc. Each of the internal rings represents either a summary statistic used in the ranking or a type of disease support used to form the summary statistics for the ranking. The first two tracks are normalized rank and rank by disease trait enrichment, respectively, and the remaining tracks 3–10 are KDG rankings per trait (Supplementary Table 16): track 3, IBD GWAS; track 4, original immune network; track 5, Crohn's disease versus control (CL)_ileum; track 6, Crohn's disease versus CL_colon; track 7, Crohn's disease versus ulcerative colitis colon; track 8, CRP; track 9, disease duration; track 10, VEO IBD genes. The color depicted in each element signifies the degree of support provided by the trait rank for the corresponding KDG, with cooler colors reflecting weaker support and hotter colors reflecting stronger support. Black asterisks denote KDGs that have already been linked to IBD experimentally. Orange asterisks indicate prioritized KDGs for experimental validation.