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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Nat Genet. 2017 Sep 11;49(10):1437–1449. doi: 10.1038/ng.3947

Figure 7.

Figure 7

Schematic of crosstalk of KDG molecular and network pathways. The icons represent multiscale datastreams from populations of patients with IBD, including DNA, RNA, and protein collected from blood and intestine of patients across different disease stages. KDG network nodes (diamonds) regulate other network nodes in subnetworks defined by the orange edges, depicting causal regulatory relationships among the network nodes. For example, the NF-κB pathway, RAC, and its actin cytoskeleton rearrangement, RAS, the NLRP3 inflammasome pathways, and TLR and chemokine receptors are modulated by the KDGs we identified, and all have been reported as associated with IBD.