Table 1. Summary table of KDG phenotypes.
| KDG-knockout mouse | KDG expression in IBD patient significantly correlated to CRP, fecal calprotectin, and/or lactoferrin | KDG expression in the intestine correlated with disease duration | Baseline FACS | Endoscopy score | Stool score | Colon weight/length ratio | H&E histology | Colitis model weight loss | Differential cytokine in macrophage KDG knockout | Network validation with enrichment of KDG knockout and knockdown signatures |
|---|---|---|---|---|---|---|---|---|---|---|
| Aif1−/− | ✓ | ✓ | ✓ | ✓ | ||||||
| Dock2−/− | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
| Dok3−/− | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| Gpsm3−/− | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ (IL-1RA, CXCL10) | ✓ | |
| Nckap1l−/− | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ (IL-6, CCL4, CXCL10) | ✓ |
H&E, hematoxylin and eosin.