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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2017 Sep 27;42(11):850–861. doi: 10.1016/j.tibs.2017.09.001

Table 1. SAGA is a conserved transcriptional co-activator complex organized into well-defined structural and functional modules.

Shown are the names of each subunit from Saccharomyces cerevisiae (sc), Saccharomyces pombe (sp), Drosophila melanogaster and Homo sapiens, according to the official nomenclature. Names in brackets are alternative, commonly used names. Paralogous subunits are separated with a “/” sign and are indicated if they have been described as part of SAGA. In most cases, paralogous subunits are mutually exclusive within SAGA complexes. Individual module subunits are coloured according to the code used in Figure 1. *The TBP binding module comprises both Spt3 and Spt8 in S. cerevisiae. In metazoans, no ortholog of scSpt8 has been found and the histone-fold domains of SUPT3H might rather contribute to SAGA structural core. #The bromodomain is found in S. cerevisiae Spt7, but not in its metazoan orthologs. @In S. pombe, there are two paralagous genes, tra1 and tra2, but only Tra1 is found in SAGA whereas Tra2 is specific for the NuA4 co-activator complex. Bromo: bromodomain; HFD: histone fold domain.

Functional tools Orthologous SAGA complexes Chromatin “reader” domains Structural domains
S. cerevisiae S. pombe D. melanogaster H. sapiens
HAT module Gcn5 Gcn5 KAT2 (GCN5) KAT2A/KAT2B (GCN5/PCAF) Bromo
Ada2 Ada2 Ada2b TADA2b SANT SWIRM
Ngg1 (Ada3) Ngg1 (Ada3) Ada3 TADA3
Sgf29 Sgf29 Sgf29 SGF29 Tudor (x2)
DUB module Ubp8 Ubp8 dNonstop USP22 (UBP22)
Sgf11 Sgf11 dSgf11 ATXN7L3 Nucleosome binding
Sgf73 Sgf73 dATXN7 ATXN7/ATXN7L1/L2
Sus1 Sus1 dE(y)2 ENY2
Core structural module Taf5 Taf5 WDA/TAF5L TAF5L WD40
Taf6 Taf6 SAF6/TAF6L TAF6L HFD
Taf9 Taf9 TAF9 TAF9/TAF9b HFD
Taf10 Taf10 TAF10b TAF10 HFD
Taf12 Taf12 TAF12 TAF12 HFD
Spt7 Spt7 Spt7 SUPT7L (STAF65G) Bromo# HFD
Hfi1 (Ada1) Hfi1 (Ada1) Ada1 TADA1 HFD
Spt20 Spt20 Spt20 SUPT20H
TBP binding* Spt3 Spt3 Spt3 SUPT3H HFD (x2)
Spt8 Spt8 - - WD40
TF binding module Tra1 Tra1@ Nipped-A( Tra1) TRRAP
Splicing module - SF3B3 SF3B3
- SF3B5 SF3B5
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