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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Mar 18;65:29–37. doi: 10.1016/j.semcdb.2016.03.015

Figure 1. Control of tissue growth by miRNAs.

Figure 1

(A) Regulated bantam expression by the Hippo and TGF pathways. Signals are transduced via the Hippo (Hpo) and Wts kinases, aided by cofactors Sav and Mats, respectively. This effectively blocks Yorkie (Yki) from entering the nucleus and activating bantam transcription. Transcription also requires either Homothorax (Hth) or Mad. Dachshund (Dach) blocks this in the eye. (B) Cross-talk between the Hippo and EGFR pathways mediated by bantam and Capicua. (C) Regulation of growth through the Hedgehog (Hh) pathway is mediated by several miRNAs. Ihog and Boi enable productive interaction between Hh and its receptor Patched (Ptc).