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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Mol Aspects Med. 2017 May 18;58:21–36. doi: 10.1016/j.mam.2017.04.006

Figure 4. Treatment of Periodontitis with Resolvin E1.

Figure 4

Periodontitis was established in the rabbit with ligature and Porphyromonas gingivalis for 6 weeks that resulted in significant alveolar bone loss at 6 weeks (Panel A). Beginning at 6 weeks, Resolvin E1 was applied topically three times per week (4 μl of a 1 μg/ml solution in PBS) for an additional 6 weeks. The vehicle treated group exhibited further bone loss (Panel B and D), while the RvE1 treated group exhibited regrowth on bone to near pre-disease levels (Panels C and D).