Skip to main content
. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Mol Aspects Med. 2017 May 18;58:21–36. doi: 10.1016/j.mam.2017.04.006

Figure 8. Atherogenesis that is accelerated by Periodontitis is slowed by RvE1.

Figure 8

0.5% cholesterol in the New Zealand White Rabbit diet induces atherogenic changes in the aorta characterized by fatty streaks that is worsened by concomitant periodontitis (136) (Panel A). The ability of RvE1 treatment of periodontitis to reverse fatty streak development is seen with increased doses of RvE1. Interestingly, in the absence of periodontitis, local application of RvE1 to the gingiva (4 μg) offered significantly greater protection from atheromatous changes (Panel B). The data confirm that periodontitis has a significant impact on the progression of atheromas in this model and suggest a potential therapeutic benefit for regulation of inflammation with resolvins in atherogenesis. [Adapted from (138)]