Table 4. Multivariable analyses showing associations of various patient and clinical characteristics with function.
| Variables | IADL Impairment (N=356) | PA Limitation (N=347) | Falls (N=350) | SPPB (N=327) | Cognitive Impairment (N=332) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Adjusted ORs (95% CI) | P-value | Adjusted ORs (95% CI) | P-value | Adjusted ORs (95% CI) | P-value | Adjusted ORs (95% CI) | P-value | Adjusted ORs (95% CI) | P-value | ||
|
| |||||||||||
| Sleep disturbance | Yes | 1.98 (1.18-3.35) | 0.01 | 2.27 (1.18-4.36) | 0.02 | 1.19 (0.75-1.81) | 0.46 | 1.05 (0.58-1.90) | 0.87 | 1.02 (0.61-1.70) | 0.95 |
|
| |||||||||||
| Gender | Female | 1.02 (0.57-1.81) | 0.95 | 1.22 (0.62-2.42) | 0.56 | 0.92 (0.53-1.58) | 0.76 | 0.95 (0.49-1.85) | 0.88 | 1.07 (0.60-1.91) | 0.82 |
|
| |||||||||||
| Age | ≤80 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| >80 | 1.17 (0.71-1.93) | 0.53 | 1.52 (0.84-2.75) | 0.16 | 1.31 (0.82-2.09) | 0.26 | 1.20 (0.68-2.12) | 0.54 | 1.89 (1.14-3.16) | 0.01 | |
|
| |||||||||||
| Race | White | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Non-white | 1.17 (0.64-2.12) | 0.62 | 0.44 (0.22-0.86) | 0.02 | 0.66 (0.37-1.17) | 0.15 | 1.22 (0.59-2.52) | 0.59 | 6.67 (3.38-13.18) | <0.0001 | |
|
| |||||||||||
| Marital Status | Married | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Widowed | 1.59 (0.88-2.90) | 0.13 | 1.47 (0.73-2.97) | 0.28 | 1.00 (0.58-1.75) | 0.99 | 1.99 (0.96-4.10) | 0.06 | 1.25 (0.70-2.25) | 0.45 | |
| Other | 1.06 (0.55-2.03) | 0.87 | 2.52 (1.01-6.27) | 0.05 | 1.22 (0.66-2.28) | 0.52 | 1.72 (0.77-3.84) | 0.19 | 0.80 (0.41-1.59) | 0.53 | |
|
| |||||||||||
| Education level | >High School | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| =High School | 1.72 (0.97-3.03) | 0.06 | 1.83 (0.89-3.75) | 0.10 | 0.94 (0.55-1.58) | 0.80 | 1.37 (0.72-2.60) | 0.33 | 2.00 (1.14-3.48) | 0.01 | |
| <High School | 1.47 (0.76-2.85) | 0.25 | 1.24 (0.58-2.67) | 0.57 | 0.79 (0.42-1.48) | 0.47 | 2.25 (0.99-5.10) | 0.05 | 3.05 (1.54-6.03) | 0.001 | |
|
| |||||||||||
| Primary cancer subtype | Other | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Lung | 1.36 (0.66-2.82) | 0.41 | 0.75 (0.31-1.80) | 0.51 | 1.32 (0.65-2.65) | 0.44 | 1.98 (0.86-4.59) | 0.11 | 1.58 (0.74-3.38) | 0.23 | |
| GI | 1.26 (0.60-2.66) | 0.54 | 1.52 (0.60-3.87) | 0.38 | 1.02 (0.49-2.11) | 0.96 | 1.57 (0.68-3.64) | 0.30 | 2.18 (0.99-4.82) | 0.05 | |
| GU | 1.24 (0.60-2.57) | 0.57 | 0.64 (0.27-1.54) | 0.32 | 1.59 (0.79-3.20) | 0.19 | 1.42 (0.63-3.20) | 0.40 | 1.59 (0.75-3.41) | 0.23 | |
|
| |||||||||||
| Stage | Limited | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Advanced | 2.16 (1.28-3.63) | 0.004 | 1.93 (1.02-3.64) | 0.04 | 2.34 (1.40-3.94) | 0.001 | 0.85 (0.46-1.57) | 0.60 | 1.89 (1.10-3.25) | 0.02 | |
| Unknown | 3.10 (1.43-6.73) | 0.004 | 2.23 (0.90-5.51) | 0.08 | 1.86 (0.93-3.73) | 0.08 | 1.76 (0.69-4.49) | 0.24 | 1.83 (0.87-3.85) | 0.22 | |
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| Comorbidity | Yes | 2.08 (1.22-3.54) | 0.007 | 2.73 (1.47-5.08) | 0.001 | 2.14 (1.23-3.70) | 0.007 | 2.75 (1.51-4.99) | 0.0009 | 1.04 (0.59-1.83) | 0.90 |
|
| |||||||||||
| Depression | Yes | 1.28 (0.73-2.25) | 0.38 | 1.86 (0.89-3.90) | 0.10 | 0.86 (0.52-1.42) | 0.55 | 1.03 (0.54-1.98) | 0.92 | 1.22 (0.71-2.10) | 0.47 |
Abbreviations: IADL, instrumental activities of daily living; PA, physical activity; SPPB, short physical performance battery; OR, odd ratio; CI; confidence interval; GU, genitourinary; GI, gastrointestinal