FIGURE 1.

Hierarchical clustering of the raw abundances of the CAZy glycosyl-hydrolase (GH) and auxiliary activity (AA) families in the bacterial species constituting the Italian pan-microbiome. Spearman distance and Ward’s minimum variance method were used. Four CAZy Co-abundance Groups (CCGs) were identified and named according to the most abundant species in each group, as follows: CCG1 – Subdoligranulum variabile group (red), CCG2 – Eubacterium rectale group (blue), CCG3 – Ruminococcus bromii group (green), and CCG4 – Faecalibacterium prausnitzii group (yellow). Below the heatplot are reported the counts of CAZyme-coding sequences belonging to the GH and AA families, detected in the type strain reference genomes for each bacterial species, divided by class of MACs: resistant starch (RS), non-digestible carbohydrates (NDC), non-starch polysaccharides (NSP), and mucins/glycoproteins (M/G).