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. 2017 Oct 24;10:337. doi: 10.3389/fnmol.2017.00337

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Copyright © 2017 Capitanio, Moriggi, De Palma, Bizzotto, Molon, Torretta, Fania, Bonaldo, Gelfi and Braghetta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histograms of differentially expressed metabolic proteins in Col6a1^−/− (blue bars) and Wt mice (red bars). Isoforms of proteins significantly altered (Student’s t-test, n = 4, p < 0.01) are expressed as % of spot volume variation in 12-month-old vs. 6-month-old mice (Aldoa: aldolase A; Eno1: enolase; Eno3: beta-enolase; Gapdh: glyceraldehyde-3-phosphate dehydrogenase; Ldhb: L-lactate dehydrogenase B; Pgam2: phosphoglycerate mutase; Pgk1: phosphoglycerate kinase 1; Pgm2: phosphglucomutase 2; Tpi1: triosephosphate isomerase 1; Aco2: aconitate hydratase; Dld: dihydrolipoamide dehydrogenase 1; Idh3a: isocitrate dehydrogenase alpha subunit; Mdh1: cytoplasmic malate dehydrogenase; Ogdh: oxoglutarate dehydrogenase; Sdha: succinate dehydrogenase; Atp5b: ATP synthase subunit beta; Etfa: electron transfer flavoprotein subunit alpha; Ndufa10: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10; Ndufs1: NADH-ubiquinone oxidoreductase 75 kDa subunit; Ndufs2: NADH-dehydrogenase iron-sulfur protein 2; Ndufs3: NADH-dehydrogenase iron-sulfur protein 3; Uqcrc1: ubiquinol-cytochrome c reductase core protein I; Ak1: adenylate kinase 1; Ckm: creatine kinase; Ckmt2: mitochondrial creatine kinase S-type).