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. 2017 Oct 24;8:748. doi: 10.3389/fphar.2017.00748

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Copyright © 2017 Alhomrani, Correia, Zavou, Leaw, Kuk, Xu, Saad, Hodge, Greening, Lim and Sievert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative images of activated HSC stained with α-SMA from control and treated groups. Scale bar = 200 μm, 10× magnification. (B) The percentage of HSC in the liver was significantly decreased in mice treated with CM, EVDM, and EV compared to CCl₄ only. (C) Concentration of TGF-β1 in liver was determined by ELISA and found to be significantly lower in mice treated with EV only. The data are represented as mean ± SEM. n = 6–8 per group, ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^∗∗∗∗P < 0.0001.