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Liver function analyses of Hepa/8F5 cell-bearing macroporous gelatin beads during long term culture. Cells were seeded at a density of 480 cells/bead on day 0 and cultured for 15 days in the presence of Dox. They were then analyzed for albumin secretion rates per cell (a), and per bead (d), for ammonia removals rates per cell (b), and per bead (e), and for CYP3A activity per cell (c), and per bead (f). The data shown are the means ± SD (n = 3)
