Table 3.
Selected studies using anti-CD40mAb in pig-to-nonhuman primate xenotransplantation.
| First author (year) | Donor pig | Recipient NHP | Immunosuppressive regimen | Longest survival (days) |
|---|---|---|---|---|
| Heart xenotransplantation, heterotopic | ||||
| Iwase (2015) [96] | GTKO.CD46.TBM | Baboon | ATG, belatacept, anti-CD40mAb, tacrolimus, MMF, CS | 130 |
| Mohiuddin (2016) [78] | GTKO.CD46.TBM | Baboon | ATG, anti-CD20mAb, anti-CD40mAb, CS | >900 |
| Kidney xenotransplantation | ||||
| Iwase (2015) [23] | GTKO.CD46.CD55 TBM.EPCR.CD39 | Baboon | ATG, anti-CD20mAb, anti-CD40mAb, rapamycin, tocilizumab, etanercept | 136 |
| Liver xenotransplantation | ||||
| Shah (2017) [24] | GTKO | Baboon | ATG, anti-CD40mAb, tacrolimus, CVF, CS | 29 |
| Islet xenotransplantation | ||||
| Thompson (2011) [21] | WT | Rhesus | Anti-CD25mAb, anti-CD40mAb, rapamycin, belatacept | 203 |
NHP: nonhuman primate; WT: wild-type; ATG: antithymocyte globulin; CVF: cobra venom factor; MMF: mycophenolate mofetil; mAb: monoclonal antibody; CS: corticosteroids; GTKO: α1,3-galactosyltransferase gene knockout; TBM: thrombomodulin; EPCR: endothelial cell protein C receptor.