Table 1.
Demographic information, neuropsychological and MRI values for cognitively normal and mild cognitive impairment patients
| Cognitively Normal (n = 38) | MCI (n = 29) | F or χ2 | p-value | |
|---|---|---|---|---|
| Age | 74.1 (SD = 7.7) | 73.7 (SD = 7.0) | 0.05 | 0.818 |
| Education | 14.7 (SD = 3.6) | 14.6 (SD = 3.5) | 0.02 | 0.904 |
| Gender | 68.4 % female | 51.7 % female | 1.29 | 0.256 |
| Ethnicity | ||||
| White Non-Hispanic | 71.1% | 65.5% | 0.51 | |
| Hispanic | 21.1% | 27.6% | (Fisher Exact Test) | |
| African-American | 7.9% | 6.9% | ||
| MMSE | 28.7 (SD = 1.6) | 26.9 (SD = 2.4) | 13.99 | <0.001 |
| HVLT-R Total Recall | 24.2 (SD = 4.6) | 17.3 (SD = 4.0) | 40.00 | <0.001 |
| HVLT-R Delay Recall | 8.9 (SD = 2.2) | 4.0 (SD = 2.2) | 79.78 | <0.001 |
| NACC Delay Passage | 12.3 (SD = 3.4) | 6.7 (SD = 3.4) | 44.36 | <0.001 |
| LASSI-L A2 Cued Recall (Maximum Storage) | 13.1 (SD = 1.5) | 11.2 (SD = 1.9) | 20.42 | <0.001 |
| LASSI-L B1 Cued Recall (Susceptible to PSI) | 7.5 (SD = 2.8) | 5.1 (SD = 2.1) | 14.96 | <0.001 |
| LASSI-L B2 Cued Recall (Recovery from PSI) | 11.2 (SD = 2.5) | 8.5 (SD = 2.4) | 20.27 | <0.001 |
| Hippocampal Volume | 0.0054 (SD = 0.0008) | 0.0048 (SD = 0.0008) | 9.74 | <0.003 |
| ERC Volume | 0.0022 (SD = 0.0003) | 0.0022 (SD = 0.0004) | 0.66 | 0.421 |
| Inferior Lateral Ventricle | 0.0008 (SD = 0.0006) | 0.0011 (SD = 0.0006) | 4.66 | 0.035 |
| Precuneus Volume | 0.0120 (SD = 0.0013) | 0.0114 (SD = 0.0012) | 3.48 | 0.067 |
| Posterior Cingulate Volume | 0.0039 (SD = 0.0005) | 0.0038 (SD = 0.0005) | 2.65 | 0.108 |
| Temporal Pole Volume | 0.0031 (SD = 0.0005) | 0.0030 (SD = 0.0006) | 0.78 | 0.381 |
| Inferior Temporal Volume | 0.0125 (SD = 0.0012) | 0.0118 (SD = 0.0014) | 5.08 | 0.028 |
| Superior Parietal Lobe | 0.0161 (SD = 0.0015) | 0.0152 (SD = 0.0012) | 6.86 | 0.011 |
| Superior Frontal Lobe Volume | 0.0259 (SD = 0.0025) | 0.0247 (SD = 0.0022) | 3.80 | 0.056 |
| Middle Frontal Lobe Volume | 0.0184 (SD = 0.002) | 0.0177 (SD = 0.0016) | 2.26 | 0.128 |
MMSE, Mini-Mental State Examination; HVLT-R, Hopkins Verbal Learning Test-Revised; NACC, National Alzheimer’s Coordinating Center; LASSI-L, Loewenstein-Acevedo Scales for Semantic Interference and Learning; ERC, entorhinal cortex.