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. 2017 Jul 10;30(4):283–289. doi: 10.1293/tox.2017-0029

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©2017 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.

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Fig. 1. — Pyknotic changes in spermatogonia and spermatocytes after 96 h MTX treatment. A. Control wild-type medaka group. B. MTX-treated wild-type medaka group. C. Control homogenic p53-deficient (p53 (−/−)) medaka group. D. MTX-treated homogenic p53-deficient (p53 (−/−)) medaka group. Arrows indicate pyknosis. Bar = 30 μm.