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. 2017 Oct 25;8:762. doi: 10.3389/fphar.2017.00762

FIGURE 9.

FIGURE 9

Effects of intra-BNST CRFR1 (CP376,395, CP) or CRFR2 (Astressin2B, A2B) antagonists on ethanol consumption in non-stressed controls and socially defeated mice exposed to continuous access to ethanol/water for 4 weeks. After infusions, mice were given continuous access to ethanol and water for 2 h, (A) 4 h and (B) 24 h. The graphs are split into non-stressed and stressed groups. Left bars represent non-stressed mice. Right bars represent socially defeated mice. Left, groups from left to right: Sal, non-stressed controls + saline, n = 20; 0.25, non-stressed controls + CP 0.25 μg/side, n = 11; 0.5, non-stressed controls + CP 0.5 μg/side, n = 11; 0.25, non-stressed controls + A2B 0.25 μg/side, n = 9; 0.5, non-stressed controls + A2B 0.5 μg/side, n = 9. Right, groups from left to right: Sal, stressed mice + saline, n = 24; 0.25, stressed mice + CP 0.25 μg/side, n = 12; 0.5, stressed mice + CP 0.5 μg/side, n = 11; 0.25, stressed mice + A2B 0.25 μg/side, n = 12; 0.5, stressed mice + A2B 0.5 μg/side, n = 12. Data are mean ± SEM. ∗versus Sal group in the same condition (Non-stressed or Stressed, p < 0.05); #versus Non-stressed + Sal group (p = 0.06).