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. 2017 Oct 25;8:2020. doi: 10.3389/fmicb.2017.02020

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Copyright © 2017 Lonien, Malvezi, Suzukawa, Yamauchi, Yamada-Ogatta, Rizzo, Bordignon and Pinge-Filho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adenylate-cyclase activity regulates the entry of T. cruzi into DC-PBMC. DC-PBMC were treated for 30 min separately either with or without SQ 22536 (20 μM) and exposed to 5:1 trypomastigotes of T. cruzi (Y strain) during 18 h. Inhibition of adenylate-cyclase decreases T. cruzi infection (A). Number of infected DC-PBMC with nine amastigotes per cell decreased with the treatment (B). Results are the mean ± standard error for duplicate determinations, with five (A) and six (B) blood donors in each experiment. Means not sharing letter are significantly different (P < 0.05, one-way ANOVA with Tukey's post-test).