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. 2017 Oct 25;8:2020. doi: 10.3389/fmicb.2017.02020

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Copyright © 2017 Lonien, Malvezi, Suzukawa, Yamauchi, Yamada-Ogatta, Rizzo, Bordignon and Pinge-Filho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The activation of adenylyl cyclase with forskolin reverted CEL effects on T. cruzi entry. DC-PBMC were treated for 30 min with forskolin (10 μM) alone or in combination with ASA (A) or with CEL (B) and exposed to 5:1 trypomastigotes of T. cruzi (Y strain) during 18 h. The activation of adenylyl cyclase with forskolin did not affect cell invasion by trypomastigotes from Y strain (P > 0.05) (A,B), but reverted CEL effects (P < 0.05) (B). Results are the mean ± standard error for duplicate determinations, with three blood donors in each experiment. Means not sharing letter are significantly different (P < 0.05, one-way ANOVA with Tukey's post-test).