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. 2017 Oct 25;8:1351. doi: 10.3389/fimmu.2017.01351

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Copyright © 2017 Xi, Troy, Anderson, Pena, Lynch, Phipps, Bosco and Upham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular drivers of human rhinoviruses strain 16 (RV16) induced gene expression. Differentially expressed genes/molecular drivers were identified in peripheral blood mononuclear cell (PBMC) (A,D) and plasmacytoid dendritic cell (pDC)-depleted PBMC (B,E) in the presence of RV16. Comparison of RV16-stimulated pDC-depleted PBMC and intact PBMC (C,F). Data analysis was performed by limma (A–C) and upstream regulator analysis (D–F). The dashed horizontal line in (A–C) indicates FDR < 0.05. Drivers in red are predicted to be activated and those in blue are inhibited.