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. 2017 Oct 25;8:1351. doi: 10.3389/fimmu.2017.01351

Figure 4.

Figure 4

Which human rhinoviruses strain 16 (RV16) responsive genes are dependent on Plasmacytoid dendritic cell (pDC) and regulated by interferon (IFN)-I? RV16 responsive genes showing >2-fold changes have been analyzed (A). Out of the total genes that are upregulated (Red) or downregulated (Blue), the numbers of pDC-dependent gene expressions have been analyzed by comparing pDC-depleted PBMC with intact PBMC. Genes that show >2-fold change are regarded as “likely to be pDC dependent”; between 1.5- and 2.0-fold changes are regarded as “possibly pDC dependent”; and <1.5-fold change and regarded as “unlikely to be pDC dependent” Numbers of genes are indicated on the pie charts (B,C). Out of the total genes that are likely to be pDC-dependent expression (>2-fold), the proportion of IFN-I-regulated gene expression has been identified using Interferome v2.01 database: (D,E). Venn diagrams show the extent to which IFN-I-regulated genes are regulated solely by IFN-I, or also regulated by multiple IFN subtypes (F,G).