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. 2017 Sep 13;77(16):1755–1768. doi: 10.1007/s40265-017-0814-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Study design of the pivotal and extension studies of fingolimod, and of the other sphingosine-1-phosphate (S1P) receptor modulators. Areas shaded gray indicate that the S1P receptor subtypes are unaffected by the drugs in each section. ^aAmiselimod is selective, but its selectivity is unknown. BOLD BAF312 on MRI lesion given once daily, DREAMS a study of the safety and efficacy of ONO-4641 in patients with relapsing–remitting multiple sclerosis, EPOC evaluate patient outcomes, EU European Union, EXPAND exploring the efficacy and safety of siponimod in patients with secondary progressive multiple sclerosis, FIRST fingolimod initiation and cardiac safety trial, FREEDOMS FTY720 research evaluating effects of daily oral therapy in multiple sclerosis, GA glatiramer acetate, IFN interferon, IM intramuscular, LONGTERMS long-term study of fingolimod in multiple sclerosis patients from the FTY clinical program, MOMENTUM a randomized, double-blind, placebo-controlled, phase II, dose-finding study of MT-1303 in subjects with relapsing–remitting multiple sclerosis, OPTIMUM oral ponesimod versus teriflunomide in relapsing multiple sclerosis, PANGAEA post authorization noninterventional German safety of Gilenya in relapsing–remitting multiple sclerosis patients, PREFERMS evaluation of patient retention of fingolimod versus currently approved disease-modifying therapy in patients with relapsing–remitting multiple sclerosis, RADIANCE safety and efficacy of the selective sphingosine-1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis, S1P _1–5 sphingosine-1-phosphate receptor subtypes 1–5, SC subcutaneous, START study to validate telemetric ECG systems for first-dose administration of fingolimod, SUNBEAM phase III study of RPC1063 in relapsing multiple sclerosis, TOFINGO disease control and safety in patients with relapsing–remitting multiple sclerosis switching from natalizumab to fingolimod, TRANSFORMS trial assessing injectable interferon versus FTY720 oral in relapsing–remitting multiple sclerosis, TRANSITION a two-year observational study to evaluate the safety profile of fingolimod in patients with multiple sclerosis who switch from natalizumab to fingolimod, VERIFY investigating the effect of recent immunization in patients receiving fingolimod therapy.

Adapted with permission from Khatri, Ther Adv Neurol Disord. 2016;9:130–47 [47]