Skip to main content
. 2017 Oct 24;8:1384. doi: 10.3389/fimmu.2017.01384

Figure 2.

Figure 2

Immunological features of the primary Sjögren’s syndrome-like disease in C3H/He mice. (A) Autoantibodies against the Ro60_316-335 peptide in sera of Ro60_316-335 immunized (n = 9) C3H/HeJ mice or controls (n = 9). Results derived from one of two experiments performed are shown and data are presented as mean ± SEM. Statistically significant differences (*p < 0.05 and **p < 0.01) were calculated by using the Mann–Whitney U-test. (B) Immunoblotting of lacrimal glands (LG) or salivary glands (SG) tissue lysates from healthy mice with sera from control or Ro60_316-335 immunized mice. Representative results are shown. (C,D) immunochemistry staining of murine CD3 T cells (C) and CD19 B cell (D) in the lymphocytic foci (bar length = 50 µm). (E) Concentrations of IFN-γ, IL-17A, IL-4, and IL-10 in the sera of Ro60_316-335 immunized C3H/HeJ mice (n = 16) and controls (n = 11). Statistically significant differences (*p < 0.05) were calculated by the Mann–Whitney U-test.