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. 2017 Oct 24;8:1381. doi: 10.3389/fimmu.2017.01381

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Copyright © 2017 Zhou, Gu, Xiao, Kang, Xie, Zhang, Shi, Hu, Oldfield, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BPH-1236 performs better and functions via inhibiting farnesyl diphosphate synthase (FPPS). (A) Response of human blood Vγ9Vδ2 T cells to zoledronate or BPH-1236 treatment. Isolated human peripheral blood mononuclear cells (PBMCs) were treated with zoledronate or BPH-1236 for 3 days, and cells were allowed to proliferate for another 9 days, followed by staining for CD3 and TCR Vδ2. (B) The rescue effect of simvastatin on the cytotoxicity of Vγ9Vδ2T cells against LX-2 cells that were pretreated with BPH-1236. ***P < 0.001. (C) The rescue effect of simvastatin on the response of human blood Vγ9Vδ2 T cells to zoledronate or BPH-1236. All data are presented as mean ± SEM of three replicates from a representative experiment of three independent experiments.