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. 2017 Oct 24;8:1381. doi: 10.3389/fimmu.2017.01381

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Copyright © 2017 Zhou, Gu, Xiao, Kang, Xie, Zhang, Shi, Hu, Oldfield, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adoptively transferred Vγ9Vδ2 T cells and BPH-1236 combine to kill activated stellate cells in an orthotopic Rag2^−/−γc^−/− mouse model. (A) Representative bioluminescence images showing orthotopic LX-2/Luc cells in Rag2^−/−γc^−/− mice on day 0 (before treatment) and day 7 (7 days after treatment), n = 5 per group. (B) Percent changes in LX-2 cells xenografts volume (luminescence value) in (A) from day 0 (baseline) to day 7 are shown for each mouse (n = 5 per group) as a waterfall plot (in comparison with control (Ctrl), γδ T cells: P < 0.01; BPH-1236: ns; BPH-1236 + γδ T cells: P < 0.05; two-tailed Student’s t-tests).