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. 2017 Oct 24;8:1381. doi: 10.3389/fimmu.2017.01381

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Copyright © 2017 Zhou, Gu, Xiao, Kang, Xie, Zhang, Shi, Hu, Oldfield, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adoptively transferred Vγ9Vδ2 T cells and BPH-1236 combine to kill hepatocellular carcinoma (HCC) tumors in an orthotopic Rag2^−/−γc^−/− mouse model. (A) Cytotoxicity (lactate dehydrogenase (LDH) assay) of Vγ9Vδ2 T cells against human Huh 7 cells pretreated with BPH-1236. Data are presented as mean ± SEM of three replicates from a representative experiment of three independent experiments. (B) Representative bioluminescence images showing volume of orthotopic Huh 7/Luc tumors in Rag2^−/−γc^−/− mice on day 0 (before treatment) and day 7 (7 days after treatment); n = 5 per group. (C) Percent changes in tumor volume (luminescence value) in (B) from day 0 (baseline) to day 7 are shown for each mouse (n = 5 per group) as a waterfall plot (in comparison with control (Ctrl), γδ T cells: P < 0.05; BPH-1236 + γδ T cells: P < 0.05; two-tailed Student’s t-tests). (D) Representative liver/tumor images from each group (n = 5 per group) at day 48 after tumor transplantation (The treatments were given at day 7 as well as day 15 after Huh 7/Luc cells transplantation). Black arrows and blue circles highlight the tumors in liver. (E) Tumor volume in (D) at day 48 after tumor transplantation. *P < 0.05; **P < 0.01.