Table 3. The percent composition of microbiota at the genus level in control and ASD subjects.
Class | Order | Family | Taxon | Mean±SEM (%) | Fold change | p-value | |
---|---|---|---|---|---|---|---|
Control | ASD | ||||||
Gammaproteobacteria | Oceanospirillales | Halomonadaceae | Halomonas | 0.12±0.06 | 1.72±0.51 | ↑ 14.61 | 0.01* |
Pseudomonadales | Pseudomonadaceae | Pseudomonas | 7.48±0.86 | 5.10±0.6 | ↓ 0.68 | 0.03* | |
Enterobacteriales | Enterobacteriaceae | Erwinia | 0.26±0.1 | 0.64±0.15 | ↑ 2.41 | 0.04* | |
Citrobacter | 0.66±0.24 | 0.08±0.05 | ↓ 0.12 | 0.02* | |||
Unclassified | 8.85±1.01 | 6.08±0.58 | ↓ 0.69 | 0.02* | |||
Alphaproteobacteria | Sphingomonadales | Sphingomonadaceae | Sphingomonas | 4.17±0.83 | 0.71±0.2 | ↓ 0.17 | 0.00** |
Rhizobiales | Rhizobiaceae | Agrobacterium | 3.83±0.96 | 0.11±0.05 | ↓ 0.03 | 0.00** | |
Unclassified 1 | 0.63±0.17 | 0.07±0.03 | ↓ 0.11 | 0.00** | |||
Unclassified 2 | 0.11±0.03 | 0.00±0.00 | ↓ 0.00 | 0.00* | |||
Bradyrhizobiaceae | Unclassified | 0.24±0.07 | 0.05±0.02 | ↓ 0.21 | 0.02* | ||
Rickettsiales | Mitochondria | Unclassified | 0.84±0.3 | 0.1±0.06 | ↓ 0.12 | 0.02* | |
Betaproteobacteria | Rhodobacterales | Rhodobacteraceae | Rhodobacter | 0.01±0.01 | 0.23±0.08 | ↑ 20.34 | 0.02* |
Burkholderiales | Comamonadaceae | Roseateles | 1.12±0.35 | 0.02±0.01 | ↓ 0.02 | 0.00** | |
Delftia | 0.22±0.08 | 0.01±0.00 | ↓ 0.05 | 0.02* | |||
Comamonas | 0.08±0.05 | 0.36±0.12 | ↑ 4.48 | 0.04* | |||
Unclassified | 0.92±0.15 | 3.79±0.49 | ↑ 4.14 | 0.00** | |||
Alcaligenaceae | Achromobacter | 2.42±0.75 | 0.05±0.03 | ↓ 0.02 | 0.00** | ||
Deltaproteobacteria | Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio | 0.04±0.02 | 0.48±0.14 | ↑ 10.88 | 0.00* |
Bacilli | Lactobacillales | Streptococcaceae | Streptococcus | 1.58±0.26 | 4.77±1.28 | ↑ 3.03 | 0.02* |
Bacillales | Staphylococcaceae | Jeotgalicoccus | 0.03±0.02 | 0.50±0.11 | ↑ 14.70 | 0.00* | |
Clostridia | Clostridiales | Unclassified | Unclassified | 1.06±0.26 | 1.87±0.26 | ↑ 1.75 | 0.04* |
Clostridiaceae | Unclassified | 0.27±0.08 | 0.70±0.18 | ↑ 2.58 | 0.04* | ||
Ruminococcaceae | Oscillospira | 0.10±0.04 | 0.47±0.14 | ↑ 4.53 | 0.02* | ||
Actinobacteria | Actinomycetales | Nocardiaceae | Rhodococcus | 0.40±0.13 | 1.56±0.43 | ↑ 3.91 | 0.02* |
Micrococcaceae | Kocuria | 0.06±0.05 | 0.30±0.08 | ↑ 4.75 | 0.01* | ||
Bacteroidia | Bacteroidales | S24-7 | Unclassified | 0.84±0.36 | 2.02±0.44 | ↑ 2.40 | 0.04* |
Flavobacteriia | Flavobacteriales | [Weeksellaceae | Cloacibacterium | 0.13±0.06 | 0.62±0.2 | ↑ 4.92 | 0.03* |
Chloroplast | Streptophyta | Unclassified | Unclassified | 3.80±0.84 | 1.68±0.38 | ↓ 0.44 | 0.03* |
Verrucomicrobiae | Verrucomicrobiales | Verrucomicrobiaceae | Akkermansia | 0.52±0.18 | 2.35±0.68 | ↑ 4.52 | 0.02* |
[Fimbriimonadia] | [Fimbriimonadales] | [Fimbriimonadaceae] | Fimbriimonas | 0.38±0.12 | 0.00±0.00 | ↓ 0.00 | 0.00** |
Deinococci | Thermales | Thermaceae | Thermus | 0.03±0.02 | 0.21±0.07 | ↑ 6.30 | 0.02* |
Microbiota at the genus level whose occupancy was significantly different in ASD subjects are presented with associated higher taxonomy levels. Microbiota with occupancy 0.1% or higher in either normal healthy or ASD subjects were considered. ↑ and ↓ denote an increase and decrease in the percent composition, respectively.
Data are the mean percentage±SEM. * and ** denote significant differences between the indicated groups at p<0.05 and p<0.01, respectively (Student's t-test).