Table 1.

Effect of RPAE on brucine transport in MDCK-MDR1 cells ($\stackrel{-}{x}\pm \mathrm{S}\mathrm{D}$, n = 3).

Groups	Papp(AP-BL)  (×10−6 cm/s)	Papp(BL-AP)  (×10−6 cm/s)	ER
1 μg/mL SSE	6.81 ± 1.76	36.72 ± 0.23	5.39 ± 0.13
1 μg/mL SSE + 1 μg/mL RPAE	5.97 ± 0.58	33.82 ± 0.67	5.66 ± 1.16
1 μg/mL SSE + 3 μg/mL RPAE	4.63 ± 1.59∗	34.65 ± 1.30	7.48 ± 0.82
1 μg/mL SSE + 6 μg/mL RPAE	4.46 ± 0.97∗	48.23 ± 1.66∗	10.81 ± 1.71
1 μg/mL SSE + 100 μM verapamil	24.98 ± 2.17#	28.78 ± 2.16#	1.15 ± 0.99

^∗ P < 0.05 with contrast to the SSE 1 μg/mL group; ^#P < 0.05 with contrast to groups without verapamil.