Figure 3.

Effect of resveratrol on the hippocampus cytoarchitecture in the CA1 region in 2, 4, 6, and 8-month treatment rats (20×). (a) Control group of 2 months. (b) Control group of 4 months. (c) Control group of 6 months. (d) Control group of 8 months. The CA1 region of the hippocampus and the arrangement of the cells are observed; the cytoarchitecture begins to be modified with respect to the increase of the age. (e) Vehicle group of 2 months. (f) Vehicle group of 4 months. (g) Vehicle group of 6 months. (h) Vehicle group of 8 months. In these groups, greater dispersion of the cells is observed. (i) Group administered with vitamin E for 2 months. (j) Vitamin E group of 4 months. (k) Vitamin E group of 6 months. (l) Vitamin E group of 8 months. During the different periods, it is observed that the CA1 region is conserved; however, the space that is observed between the cells is remarkable. (m) Group administered with resveratrol for 2 months. (n) Group administered with resveratrol for 4 months. (o) Resveratrol group of 6 months. (p) Resveratrol group of 8 months. The structure of CA1 is shown with an order in the arrangement of the cells and the axonal projections are observed aligned, the integrity of the structure is conserved largely and the scattered cells are scarce, and even at 8 months, the resveratrol group is observed with less cellular disorganization. The arrows indicate areas where cells are scattered in the CA1 region.