Skip to main content
. 2017 May 4;21(11):2695–2710. doi: 10.1111/jcmm.13185

Figure 2.

Figure 2

A NLRP3 inhibitor reduced inflammation induced by benzoyl adenosine 5′‐triphosphate (BzATP) in the hearts of lipopolysaccharide (LPS)‐primed rats. (A) Representative Western blot showing that the NLRP3 inhibitor abolished the augmentation of cleaved caspase‐1 (P20) and mature IL‐1β induced by BzATP in the LPS‐primed model. LPS alone significantly increased NLRP3 (120 kD) levels but failed to induce the production of cleaved caspase‐1 (20 kD) and mature IL‐1β (17 kD. BzATP enabled a large increase in the expression of cleaved caspase‐1 and mature IL‐1β upon LPS priming, and the NLRP3 inhibitor abolished the pro‐inflammatory response of BzATP (B–D); n = 6 rats per group. Each column with a bar represents the mean ± S.D. *P < 0.05 versus naive; **P < 0.01 versus naive; † P < 0.05 versus LPS; and # P < 0.05 versus LPS + BzATP.