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. 2017 May 30;21(11):3023–3043. doi: 10.1111/jcmm.13213

Figure 1.

Figure 1

HBx inhibits miR‐384 expression in HBV‐related HCC. (A) Analysis of 80 paired tumour tissue samples, adjacent non‐tumour tissue samples and 20 normal tissue samples showing that the expression of miR‐384 was decreased in tumour tissues compared with non‐tumour tissues and normal tissues. (B) The expression of miR‐384 was decreased in 63.75% (51/80) HCC tissue samples compared with their adjacent normal controls. (C) HBV‐infected HCC patients exhibited lower expression levels of miR‐384 than HBV‐negative HCC patients. (D) HCC patients were divided according to tumour stage. The expression of miR‐384 was lower in patients with TNM III and IV than TNM I and II. (E) Kaplan–Meier survival curves in 80 patients with HCC according to the miR‐384 expression status. The results showed that low miR‐384 expression was predictive of a poor prognosis in HCC patients. The log‐rank test suggested that the difference was significant between the low miR‐384 expression group and the high miR‐384 expression group (P = 0.026). (F) miR‐384 expression was down‐regulated in HBV‐infected cells and HBx‐transfected cells compared with control cells. *P value <0.05.