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. 2017 May 30;21(11):3023–3043. doi: 10.1111/jcmm.13213

Figure 4.

Figure 4

Analysis of the expression level of PTN and miR‐384 in serum samples. (A) Serum PTN expression was higher in HCC tissues than in healthy volunteers, and PTN expression was also higher in hepatitis tissues and hepatic cirrhosis tissues samples than in normal liver samples. PTN expression was highest in HBV‐related cirrhosis patients, and it was higher in HBV‐related HCC patients than in non‐HBV‐related HCC patients (P < 0.05). (B) The ability of hepatitis B virus replication to down‐regulate the expression of PTN (C) The serum PTN level rose slightly in 2‐day post‐operative blood samples compared with the pre‐operative blood samples (P > 0.05), but there was a gradual decline in the 14 and 28‐day postoperative blood samples. (D) Serum miR‐384 levels were significantly lower in tumour samples than in control samples (P < 0.05). Serum miR‐384 levels were lower in HBV‐related HCC patients than in non‐HBV‐infected HCC patients. (E) Inhibition of hepatitis B virus replication could up‐regulate the expression of miR‐384 in HBV‐related HCC. (F) The correlation between miR‐384 serum levels and PTN serum levels in HCC patients and healthy persons. A significant negative correlation was observed between miR‐384 serum levels and PTN serum levels (r = −0.6435, P < 0.0001)