Figure 9.

High glucose may promote the expression of PTN and lipogenesis of hepatocyte. miR‐384 plays an important role in the lipogenesis of hepatocytes. (A) High glucose may promote PTN expression. SP600125 suppresses high glucose‐induced PTN expression. (B) High glucose triggered Akt phosphorylation and activated downstream mTORC1, leading to increased triglyceride levels and up‐regulation of the expression of lipogenic genes such as SREBP‐1c, FAS. Using high glucose‐treated hepatocytes as control cells, our results showed that the expression of PTN, SREBP1c and FAS, as well as the levels of AKT and mTORC1 phosphorylation, was decreased in high glucose‐induced Huh‐7 cells treated with miR‐384 compared with control cells. *P < 0.05.