Figure 2.

Loss of dopamine neurons impairs locomotion. (A) Representative images of tyrosine hydroxylase (TH) loss in the striatum (above) and substantia nigra (below) of each lesion group compared to sham. (B) Semiquantification optical density measurements of TH immunoreactivity relative to contralateral hemisphere in the striatum and midbrain. (C) Net ipsilateral turns (ipsilateral minus contralateral turns) following methamphetamine administration. (D) Average speeds of rats tracked throughout the study. Intra-STR, group with injections of 6-OHDA in the striatum; MFB, medial forebrain bundle/group with injections of 6-OHDA in the medial forebrain bundle.