Table 1.
Clinical, Demographic, and Neuropathological Characteristics by Diagnosis Category
| Clinical Diagnosis |
|||||
|---|---|---|---|---|---|
| Characteristics | NCI (n = 14) | MCI (n = 11) | AD (n = 11) | p Value | Pairwise |
| Comparison | |||||
| Age (years) at death | 0.1* | - | |||
| Mean ± SD | 83.9 ± 4.5 | 84.4 ± 5.2 | 86.2 ± 5.1 | ||
| Range | 76-92 | 72-91 | 78-95 | ||
| Number (%) of males | 6 (43%) | 6 (54%) | 6 (54%) | 0.5† | - |
| Years of education | 0.1* | - | |||
| Mean ± SD | 19.1 ± 2.9 | 18.9 ± 4.3 | |||
| Range | 15-22 | 8-24 | 14-21 | ||
| Number (%) with ApoE ∊4 allele | 2 (14%) | 2 (18%) | 5 (45%) | 0.01† | AD >NCI, MCI |
| MMSE | <0.0001* | NCI, MCI >AD | |||
| Mean ± SD | 28.1 ± 0.9 | 26.8 ± 2.6 | 15.1 ± 7.7 | ||
| Range | 26-29 | 22-30 | 0-27 | ||
| Global cognitive score | <0.0001* | NCI, MCI >AD | |||
| Mean ± SD | 0.0 ± 0.3 | -0.37 ± 0.4 | -1.8 ± 0.6 | ||
| Range | -0.5 to 0.4 | -1.2 to 0.3 | -2.8 to −0.7 | ||
| Postmortem interval (h) | 0.3* | - | |||
| Mean ± SD | 4.7 ± 2.9 | 6.0 ± 3.3 | 5.4 ± 3.4 | ||
| Range | 2.2-12.0 | 2.7-13.0 | 2.7-12.0 | ||
| Distribution of Braak scores | 0.1* | ||||
| 0 | 0 | 0 | 0 | ||
| I/II | 5 | 4 | 2 | ||
| III/IV | 8 | 6 | 6 | ||
| V/VI | 1 | 1 | 3 | ||
| NIA-Reagan diagnosis (likelihood of AD) | 0.2* | ||||
| No AD | 0 | 0 | 0 | ||
| Low | 6 | 6 | 5 | ||
| Intermediate | 6 | 5 | 5 | ||
| High | 2 | 0 | 1 | ||
| CERAD diagnosis | 0.2* | ||||
| No AD | 3 | 4 | 3 | ||
| Possible | 3 | 2 | 2 | ||
| Probable | 6 | 3 | 5 | ||
| Definite | 2 | 2 | 1 | ||
*
Kruskal-Wallis test, with Bonferroni correction for multiple comparisons.
†
Fisher's exact test, with Bonferroni correction for multiple comparisons.