Table 1.
Characteristics of aging hyperandrogenemic (DHT) female rats compared to placebo controls
BW (g) | LKW (g) | LKW/BW | Hct (%) | DHT (pg/mL) | MAP (mmHg) | GFR (mL/min/g·KW) | RPF (mL/min/g·KW) | FF | |
---|---|---|---|---|---|---|---|---|---|
Control (n = 6/grp) | 309.33 ± 8.87 | 0.838 ± 0.021 | 0.0027 ± 0.0001 | 39 ± 2 | 79.26 ± 9.93 | 110 ± 5 | 1.004 ± 0.087 | 4.08 ± 0.56 | 0.25 ± 0.01 |
DHT (n = 6/grp) | 420.83 ± 18.46 | 1.492 ± 0.113 | 0.0035 ± 0.0003 | 47 ± 2 | 272.98 ± 87.08 | 130 ± 6 | 0.422 ± 0.083 | 2.31 ± 0.45 | 0.18 ± 0.01 |
t‐test (P value) | 0.0001 | <0.0001 | 0.0343 | 0.0025 | 0.0386 | 0.0141 | 0.0003 | 0.0223 | 0.005 |
BW, body weight; LKW, left kidney weight; LKW/BW, Left kidney weight to body weight ratio; DHT, plasma dihydrotestosterone levels; MAP, mean arterial pressure; GFR, glomerular filtration rate; RPF, renal plasma flow; FF, filtration fraction.