Table 1.
Baseline characteristics of the included studies; CTD: chlorthalidone; HCTZ: hydrochlorothiazide; IND: indapamide; IND SR: indapamide sustained release tablet; metoprolol; XL: metoprolol extended release; AZL‐M/CLD: azilsartan medoxomil/chlorthalidone single‐pill combination; AZL‐M + HCTZ: azilsartan medoxomil + hydrochlorothiazide co‐administered
| Study (author, year) | BP inclusion criteria | Quality score | Subjects (N) | Interventions | Duration of washout and run‐in (weeks) | Duration of treatment (weeks) | Results measurement |
|---|---|---|---|---|---|---|---|
| Radevski et al. (2002) | Sitting DBP 95‐115 mmHg | 3 | 42 | 12.5 mg HCTZ vs. 2.5 mg IND | 3 | 12 | 24‐hr ABPM |
| David et al. (1999) | Sitting DBP 95–105 mmHg | 3 | 39 | 25 mg HCTZ vs. 2.5 mg IND | 4 | 24 | Supine BP |
| GERARD et al. (1983) | Sitting DBP ≥ 95 mmHg | 3 | 24 | 50 mg HCTZ vs. 2.5 mg IND | 6 | 12 | Recumbent BP |
| A.Pareek et al. (2009) | SBP 140–179 mmHg or DBP 90–109 mmHg | 3 | 60 | 50 mg Metoprolol XL + 6.25 mg CTD vs. 50 mg Metoprolol XL + 12.5 mg HCTZ; | 1 | 8 | Seated BP; plasma potassium record |
| Leonetti et al. (2004) |
Supine DBP 95–114 mmHg Supine SBP 161–209 mmHg |
4 | 354 | 25 mg HCTZ vs. 1.5 mg Indapamide SR | 4 | 12 | Supine BP |
| Kwon et al. (2012) | Never treated HTN(SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg) | 3 | 28 | 8 mg Candesartan + 25 mg HCTZ vs. 8 mg Candesartan + 12.5 mg CTD | 4 | 8 | Supine brachia BP |
| Michael et al. (2006) | SBP 140–179 mmHg or DBP 90–109 mmHg | 4 | 24 | Firstly: 12.5 mg CTD vs. 25 mg HCTZ; at week 4: force‐titrated to 25 mg CTD vs. 50 mg HCTZ | 4 | 8 | 24‐hr ABPM |
| Pareek et al. (2009) | SBP 140–179 mmHg or DBP 90–109 mmHg | 3 | 120 | 25 mg Losartan + 6.25 mg CTD vs. 25 mg Losartan + 12.5 mg HCTZ | 2 | 4 | Office blood pressure measurement |
| Senior et al. (1993) | DBP 95–120 mmHg | 4 | 40 | 25 mg HCTZ vs. 2.5 mg IND | 2 | 24 | Diastolic blood pressure |
| Siegel et al. (1992) | DBP 90–105 mmHg | 5 | 233 | 50 mg HCTZ vs. 50 mg CTD | 4 | 8 | 24‐hr Holter monitoring and laboratory tests |
| Bakris et al. (2012) | Seated SBP 160–190 mmHg | 4 | 587 | 40 mg AZL‐M/12.5 mg CTD vs. 40 mg AZL‐M + 12.5 mg HCTZ | 4 | 4 | 24‐hr mean BP |
| Anil K. Pareek et al. (2016) | Office SBP between 140 and 159 mmHg and DBP between 90 and 99 mmHg | 5 | 34 | 12.5 mg HCTZ vs. 6.25 mg CTD | 2 | 12 | 24‐hr ambulatory blood pressure monitoring |