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HNF-1β controls the expression of PPARGC1A and its target genes. (A and B) siRNA-mediated inhibition and plasmid-related overexpression of HNF-1β in HK-2 cells leads to dramatic down- or upregulation of PPARGC1A and its target genes, ATPG1A and IDH3A, respectively. *P<0.05; **P<0.01; ***P<0.001.
