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PPARGC1A is dramatically downregulated in mouse proximal tubule cells with HNF-1β invalidation. (A and B) In MCT cells with CRISPR/Cas9-mediated Hnf1b invalidation, target genes of HNF-1β and Ppargc1a are significantly downregulated at both mRNA and protein levels. *P<0.05; **P<0.01; ***P<0.001.
